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Prempro Information
Uses
Prempro is a combination of hormones (estrogen
and progestin) used to treat menopausal symptoms (e.g.,
hot flashes, vaginal dryness). It is also used to prevent
bone loss (osteoporosis) in people at high risk. If
you are only being treated for vaginal menopause symptoms,
products applied locally such as vaginal creams, tablets,
or rings should be considered before products taken
by mouth or absorbed through the skin. There are several
medicines (e.g. raloxifene or bisphosphonates) that
are safe and effective to prevent or treat bone loss.
These medicines should be considered for use before
estrogen/progestin HRT for osteoporosis. If you have
other medical conditions as well and are prescribed
estrogen/progestin HRT for more than one condition,
consult your doctor about your treatment plan and its
options.
How To Use
Follow the directions for using Prempro provided
by your doctor. PREMPRO COMES with a patient information
leaflet. Read it carefully. Ask your doctor, nurse,
or pharmacist any questions that you may have before
using Prempro. Prempro is usually taken
once daily. Prempro may be taken with food or
immediately after a meal to prevent stomach upset. TRY
TO TAKE PREMPRO at the same time every day. STORE
PREMPRO at room temperature between 68 and 77
degrees F (20 and 25 degrees C), away from heat, moisture,
and light. Brief storage between 59 and 86 degrees F
(15 and 30 degrees C) is permitted. IF YOU MISS A DOSE
OF PREMPRO, take it as soon as possible. If it
is almost time for your next dose, skip the missed dose
and go back to your regular dosing schedule. DO NOT
take 2 doses at once.
Side Effects
SIDE EFFECTS that may go away during treatment, include
dizziness, lightheadedness, headache, stomach upset,
bloating, irritability, changes in sleep patterns, fatigue,
nausea, weight changes, increased or decreased interest
in sex, or breast tenderness. If they continue or are
bothersome, check with your doctor. CHECK WITH YOUR
DOCTOR IMMEDIATELY if you experience mental or mood
changes (e.g., severe depression, memory loss); calf
pain or swelling; sudden severe headache; chest pain;
trouble breathing; one-sided weakness; slurred speech;
vision changes (e.g., change in contact lens fit, loss
of vision); breast lumps; swelling of hands and feet;
changes in vaginal bleeding (e.g., spotting, breakthrough
bleeding, or prolonged bleeding); unusual vaginal discharge,
itching, or odor; or yellowing of eyes or skin. AN ALLERGIC
REACTION to Prempro is unlikely, but seek immediate
medical attention if it occurs. Symptoms of an allergic
reaction include rash, itching, swelling, severe dizziness,
or trouble breathing. If you notice other effects not
listed above, contact your doctor, nurse, or pharmacist.
Precautions
KEEP ALL DOCTOR AND LABORATORY APPOINTMENTS while you
are using Prempro. You should have a complete
physical examination, including blood pressure measurements,
breast and pelvic examinations, and a PAP test (for
vaginal cancer), at least once a year. You should also
have periodic mammograms as determined by your doctor.
Follow your doctor's instructions for examining your
own breasts, and report any lumps immediately. DO NOT
INCREASE YOUR DOSE, take Prempro more often than
prescribed, or stop taking Prempro without checking
with your doctor. BEFORE YOU HAVE SURGERY, or will be
confined to a chair or bed for a long period of time
(e.g., a long plane flight), tell the doctor that you
are using Prempro. Special precautions may need
to be taken in these circumstances while you are taking
Prempro. PREMPRO MAY AFFECT CERTAIN LAB
TEST RESULTS. Make sure your doctors and laboratory
personnel know you are using Prempro. PREMPRO
MAY CAUSE DIZZINESS. DO NOT DRIVE, OPERATE MACHINERY,
OR DO ANYTHING ELSE THAT COULD BE DANGEROUS until you
know how you react to Prempro. Limit alcoholic
beverages. PREMPRO MAY CAUSE dark skin patches
on your face (melasma). Exposure to the sun may make
these patches darker. If patches develop, consult your
doctor about the use of sunscreen or protective clothing
when exposed to the sun, sunlamps, or tanning booths.
SMOKING WHILE USING PREMPRO may increase your
risk of blood clots (especially in women over the age
of 35). DO NOT USE PREMPRO if you are pregnant.
IF YOU SUSPECT THAT YOU COULD BE PREGNANT, contact your
doctor immediately. IT IS UNKNOWN IF PREMPRO IS
EXCRETED IN BREAST MILK. DO NOT BREAST-FEED while using
Prempro.
Drug Interactions
Drug interactions can result in unwanted side effects
or prevent a medicine from doing its job. Use our drug
interaction checker to find out if your medicines interact
with each other.
Overdose
If overdose is suspected, contact your local poison
control center or emergency room immediately. Symptoms
of overdose may include severe nausea and vomiting,
and excessive vaginal bleeding.
Notes
Non-drug therapy to help prevent bone loss includes
a weight-bearing exercise plan and adequate daily calcium
and vitamin D. Consult your doctor or pharmacist for
more details. DO NOT SHARE PREMPRO with others
for whom it was not prescribed. DO NOT USE PREMPRO
for other health conditions. KEEP PREMPRO out
of the reach of children and pets. IF USING PREMPRO
FOR AN EXTENDED PERIOD OF TIME, obtain refills before
your supply runs out.
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